Persuasive evidence that higher levels of TMAO lead to higher incidence of heart attacks and heart failure. TMAO comes from byproducts of eating animal products, dairy, eggs, meat. TMAO seems to work in at least two ways on increasing death by heart attack/failure. High TMAO blood serum levels increase macrophage cholesterol intake, and (I think) these macrophages are found in atherosclerosis plaques, so TMAO fills these phages with cholesterol faster--my interpretation; video doesn't get into this. Further, high TMAO levels are associated with increased incidence of heart failure in patients already suffering from weak heart. Much of these findings have been replicated multiple times.