Fire and Poison - These two mix together to cause a massive explosion that leaves the target on fire and poisoned.
Fire and Water - Creates a cloud of steam and smoke, making it impossible to be hit by ranged attacks.
Water and Lightning - This makes the water get electrified, shocking and stunning anyone in the water.
Bless and Water - Creates a pool of blessed water, healing everyone standing in it.

If you don't care about cheesing the game hardcore..... Make stacks of 1 gold coin on the character who's doing the pickpocketing then drag the 1 gold coin to whatever you want on the NPC. Doesn't matter if its above your skill to take or not. It will swap the coin and the item and it won't increase either of the bars. So, you can completely clean out an NPC if you wanted.

mklink /D "C:\Users\Whitson\Documents\My Games\Darksiders" "C:\Users\Whitson\Dropbox\Game Saves\Darksiders"